Latest Publications
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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress.
The role of senescent cells in ageing
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders.
Review: a meta-analysis of GWAS and age-associated diseases.
This finding confirms the well-established pathogenic role of MHC polymorphisms in the development of diverse autoimmune diseases. Therefore, while the association of the MHC locus with autoimmune diseases is not surprising, this finding serves as a positive control for the analysis.
In The Press
It is increasingly being recognized that directly targeting the aging process, as opposed to individual aging-related diseases or symptoms, is a viable strategy.
Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions
Beneficial Effects of Resveratrol Administration—Focus on [...]
Resveratrol: A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin
Resveratrol: A Unique Antioxidant Offering a [...]
Cancer Prevention and Treatment with Resveratrol
Cancer Prevention and Treatment with Resveratrol [...]
Resveratrol Neuroprotection in Stroke and Traumatic CNS injury
Resveratrol Neuroprotection in Stroke and Traumatic [...]
Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1
Neuroprotective Mechanisms of Resveratrol in Alzheimer's [...]
A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol
A Molecular Mechanism for Direct Sirtuin [...]
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Clearance of p16Ink4a-positive senescent cells delays [...]
On-Going Research
A new breakthrough in anti-aging research could lead to gene and stem cell therapies that turn back the hands of time.
A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations
A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations Results are encouraging In recent years, the wealth [...]
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan Results are encouraging Cellular senescence, a stress-induced irreversible growth arrest often characterized by p16Ink4a expression and a distinctive secretory [...]
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice Results are encouraging Senescent cells (SCs) accumulate with age and after genotoxic [...]
