Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

Results are encouraging

Numerous in vitro studies have shown promising results of resveratrol usage as antioxidant, antiplatelet or anti-inflammatory agent. Beneficial effects of resveratrol activity probably result from its ability to purify the body from ROS (reactive oxygen species), inhibition of COX (cyclooxygenase) and activation of many anti-inflammatory pathways.

Anaysis and further testing

Resveratrol-induced an increase in Sirtuin-1 level, which by disrupting the TLR4/NF-κB/STAT signal cascade (toll-like receptor 4/nuclear factor κ-light-chain enhancer of activated B cells/signal transducer and activator of transcription) reduces production of cytokines in activated microglia. Resveratrol caused an attenuation of macrophage/mast cell-derived pro-inflammatory factors such as PAF (platelet-activating factor), TNF-α (tumour necrosis factor-α and histamine. Endothelial and anti-oxidative effect of resveratrol may contribute to better outcomes in stroke management. By increasing BDNF (brain-derived neurotrophic factor) serum concentration and inducing NOS-3 (nitric oxide synthase-3) activity resveratrol may have possible therapeutical effects on cognitive impairments and dementias especially in those characterized by defective cerebrovascular blood flow.

A positive result

The moderation of free radicals creation and proinflammatory response diminishment may prove to be helpful in slowing down atherosclerosis development as well as in limiting the changes connected to chronic hyperglycaemia. Potential properties stimulating neuronal renewal, if proven, would find application in the treatment of various forms of dementia. If resveratrol is demonstrated to have clinically meaningful anti-sclerotic activity in humans, one potential application may be to reduce the burden of certain neurodegenerative disorders. In perspective of future findings, it is worth to consider the use of not only resveratrol alone but also its derivatives with preferable effects. Studies assessing beneficial effects of RV on cardiovascular system need to be strengthened in order to plausibly evaluate its usability. Wide spread of dosage used with similar effect makes it difficult to determine the proper dose. Additional studies are essential to verify efficacy of resveratrol in conditions specified in the paper.

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