Diving Into The Deep
According to the GenAge database, we now know of >2000 genes that modulate longevity in model organisms, and the drug database lists >400 compounds that can increase longevity in model organisms.
Most aging-related genes and pathways have not yet been targeted pharmacologically. Given the volumes of data generated in the life sciences, various approaches in computational and systems biology have been developed to help identify and rank new candidates, identify regulatory genes, and gather biological insights, as reviewed in. Such approaches are imperative, as is the integration of differing expertise in developing and prioritizing targets, drugs, and therapies for testing.
Data-Driven Analysis
SIRT1 is a protein that is believed to play important roles in longevity and age-related diseases. Previous studies have shown that when cells age, SIRT1 expression decreases, while induction and activation of SIRT1 have been associated with extended lifespan. These studies have triggered the search for SIRT1 activators that may be used as dietary supplements to promote health and longevity.
The Cellular Anti-aging Assay (SIRT1 assay) determines the ability of a test material to stimulate SIRT1 protein expression or activity in human cells, which translates to the material’s anti-aging potential.
Research
A new breakthrough in anti-aging research could lead to gene and stem cell therapies that turn back the hands of time.
Discovery
evolutionarily conserved life-extending genes and pathways are important targets for drug discovery
Analysis
The Cellular Anti-aging Assay (SIRT1 assay) determines the ability of a test material to stimulate SIRT1 protein expression or activity in human cells, which translates to the material’s anti-aging potential.
Testing
Such approaches are imperative, as is the integration of differing expertise in developing and prioritizing targets, drugs, and therapies for testing.