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Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

By |2020-08-23T19:07:48+01:00June 30th, 2020|Categories: In the press|

Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions Results are encouraging Numerous in vitro studies have shown promising results of resveratrol usage as antioxidant, antiplatelet or anti-inflammatory agent. Beneficial effects of resveratrol activity probably result from its ability to purify the body from ROS (reactive oxygen [...]

Resveratrol: A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin

By |2020-08-24T13:47:17+01:00June 30th, 2020|Categories: In the press|

Resveratrol: A Unique Antioxidant Offering a Multi-Mechanistic Approach for Treating Aging Skin Results are encouraging Resveratrol is an important polyphenol with numerous known health benefits. Working through multiple pathways this powerful antioxidant can improve the function of multiple organ systems including the skin. Resveratrol holds great promise as a topical [...]

Cancer Prevention and Treatment with Resveratrol

By |2020-08-21T21:23:10+01:00June 30th, 2020|Categories: In the press|

Cancer Prevention and Treatment with Resveratrol Results are encouraging From the studies described in this review, it is clear that resveratrol holds great potential not only in the prevention but also in the therapy of a wide variety of cancers. Tumor cells use multiple survival pathways to prevail over normal [...]

Resveratrol Neuroprotection in Stroke and Traumatic CNS injury

By |2020-08-23T19:14:50+01:00June 29th, 2020|Categories: In the press|

Resveratrol Neuroprotection in Stroke and Traumatic CNS injury Results are encouraging The sum of the above presented investigations suggests that resveratrol is a potent pharmacological agent that can prevent secondary damage after stroke and acute CNS injury. Furthermore, resveratrol pretreatment is a viable option to induce ischemic tolerance. The beneficial [...]

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

By |2020-08-23T19:19:44+01:00June 29th, 2020|Categories: In the press|

Neuroprotective Mechanisms of Resveratrol in Alzheimer's Disease: Role of SIRT1 Results are encouraging Alzheimer's disease (AD) is a progressive and neurodegenerative disorder of the cortex and hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD remains unclear, the presence of β-amyloid (Aβ) peptides in these learning and memory [...]

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol

By |2020-08-23T19:38:33+01:00June 29th, 2020|Categories: In the press|

A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol Results are encouraging Sirtuins are protein deacetylases regulating metabolism, stress responses, and aging processes, and they were suggested to mediate the lifespan extending effect of a low calorie diet. Sirtuin activation by the polyphenol resveratrol can mimic such lifespan extending effects [...]

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

By |2020-08-23T19:40:55+01:00December 4th, 2019|Categories: Latest Publications|

Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress.

A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations

By |2020-08-23T19:46:48+01:00November 18th, 2019|Categories: On-going research|

A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations Results are encouraging In recent years, the wealth of basic science research supporting resveratrol's potential to treat, delay, and even prevent age-related chronic diseases has led to a number of human clinical trials. [...]

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

By |2020-08-23T19:56:48+01:00November 18th, 2019|Categories: On-going research|

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan Results are encouraging Cellular senescence, a stress-induced irreversible growth arrest often characterized by p16Ink4a expression and a distinctive secretory phenotype, prevents the proliferation of preneoplastic cells and has beneficial roles in tissue remodelling during embryogenesis and wound healing. Senescent cells accumulate in various tissues [...]

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