Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice Results are encouraging Senescent cells (SCs) accumulate with age [...]
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders.
This finding confirms the well-established pathogenic role of MHC polymorphisms in the development of diverse autoimmune diseases. Therefore, while the association of the MHC locus with autoimmune diseases is not surprising, this finding serves as a positive control for the analysis.
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders Results are encouraging Advanced age is the main risk factor for most chronic diseases [...]