A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations

By |2020-08-23T19:46:48+01:00November 18th, 2019|Categories: On-going research|

A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations Results are encouraging In recent years, the wealth of basic science research supporting resveratrol's potential to treat, delay, and even prevent age-related chronic diseases has led to a number of human clinical trials. [...]

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

By |2020-08-23T19:56:48+01:00November 18th, 2019|Categories: On-going research|

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan Results are encouraging Cellular senescence, a stress-induced irreversible growth arrest often characterized by p16Ink4a expression and a distinctive secretory phenotype, prevents the proliferation of preneoplastic cells and has beneficial roles in tissue remodelling during embryogenesis and wound healing. Senescent cells accumulate in various tissues [...]

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

By |2020-08-24T13:55:44+01:00November 18th, 2019|Categories: On-going research|

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice Results are encouraging Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI)1–6. Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders7, suggesting that SCs [...]

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