A healthier approach to clinical trials evaluating resveratrol for primary prevention of age-related diseases in healthy populations Results are encouraging In recent years, the wealth of basic science research supporting resveratrol's potential to treat, delay, and even prevent age-related chronic diseases has led to a number of human clinical trials. [...]

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan Results are encouraging Cellular senescence, a stress-induced irreversible growth arrest often characterized by p16Ink4a expression and a distinctive secretory phenotype, prevents the proliferation of preneoplastic cells and has beneficial roles in tissue remodelling during embryogenesis and wound healing. Senescent cells accumulate in various tissues [...]

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice Results are encouraging Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI)1–6. Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders7, suggesting that SCs [...]